biostudies-literatureConway Morris AInnovate UKBD BiosciencesNational Institute for Health Research (NIHR)National Institute for Academic AnaesthesiaWellcome Trust627-635https://www.ebi.ac.uk/biostudies/studies/S-EPMC6006236biostudies-literatureUnknown44(5)<h4>Purpose</h4>Cellular immune dysfunctions, which are common in intensive care patients, predict a number of significant complications. In order to effectively target treatments, clinically applicable measures need to be developed to detect dysfunction. The objective was to confirm the ability of cellular markers associated with immune dysfunction to stratify risk of secondary infection in critically ill patients.<h4>Methods</h4>Multi-centre, prospective observational cohort study of critically ill patients in four UK intensive care units. Serial blood samples were taken, and three cell surface markers associated with immune cell dysfunction [neutrophil CD88, monocyte human leucocyte antigen-DR (HLA-DR) and percentage of regulatory T cells (T_regs)] were assayed on-site using sIntensive care medicineCell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.PMC600623610119316/33/01205214/Z/16/ZEME/16/33/01CS-2016-16-011WT 2055214/Z/16/ZWeir CJAntonelli JWang AJudge KWarner NLewis SMMare TRossi AGBurpee TRoy AIDatta DShankar-Hari MConway Morris AHulme GRennie JDimmick ISimpson AJKeenan JStephen JWalsh TSBateman ABrown KAfalseCell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.<h4>Purpose</h4>Cellular immune dysfunctions, which are common in intensive care patients, predict a number of significant complications. In order to effectively target treatments, clinically applicable measures need to be developed to detect dysfunction. The objective was to confirm the ability of cellular markers associated with immune dysfunction to stratify risk of secondary infection in critically ill patients.<h4>Methods</h4>Multi-centre, prospective observational cohort study of critically ill patients in four UK intensive care units. Serial blood samples were taken, and three cell surface markers associated with immune cell dysfunction [neutrophil CD88, monocyte human leucocyte antigen-DR (HLA-DR) and percentage of regulatory T cells (T_regs)] were assayed on-site using s2018-01-01T00:00:00Z2018 May2026-04-29T05:02:53.45Z2019-03-26T23:44:19ZS-EPMC60062362991594110.1007/s00134-018-5247-0