{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Q"],"funding":["NCI NIH HHS"],"pagination":["1066-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6007862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(6)"],"pubmed_abstract":["<h4>Purpose</h4>To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice.<h4>Methods</h4>Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives.<h4>Results</h4>Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) t"],"journal":["Pharmaceutical research"],"pubmed_title":["Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice."],"pmcid":["PMC6007862"],"funding_grant_id":["R01CA139959","R01 CA139959"],"pubmed_authors":["Pan J","Ryota S","He J","Fu H","Lubet RA","You M","Hara Y","Wang Y","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.","description":"<h4>Purpose</h4>To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice.<h4>Methods</h4>Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives.<h4>Results</h4>Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) t","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2025-04-21T19:18:57.897Z","creation":"2019-03-26T23:42:32Z"},"accession":"S-EPMC6007862","cross_references":{"pubmed":["20112129"],"doi":["10.1007/s11095-010-0056-3"]}}