biostudies-literatureZhang QNCI NIH HHS1066-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC6007862biostudies-literatureUnknown27(6)<h4>Purpose</h4>To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice.<h4>Methods</h4>Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives.<h4>Results</h4>Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) tPharmaceutical researchEffect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.PMC6007862R01CA139959R01 CA139959Pan JRyota SHe JFu HLubet RAYou MHara YWang YZhang QfalseEffect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.<h4>Purpose</h4>To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice.<h4>Methods</h4>Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives.<h4>Results</h4>Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) t2010-01-01T00:00:00Z2010 Jun2025-04-21T19:18:57.897Z2019-03-26T23:42:32ZS-EPMC60078622011212910.1007/s11095-010-0056-3