biostudies-literaturePalacios-Munoz AMillennium Scientific Initiative of the Ministerio de Economia, Fomento y TurismoOffice of Naval Research Global (US)Consejo Nacional de Innovación, Ciencia y TecnologíaFONDECYTe1007433https://www.ebi.ac.uk/biostudies/studies/S-EPMC6007936biostudies-literatureUnknown14(6)Circadian clocks impose daily periodicities to animal behavior and physiology. At their core, circadian rhythms are produced by intracellular transcriptional/translational feedback loops (TTFL). TTFLs may be altered by extracellular signals whose actions are mediated intracellularly by calcium and cAMP. In mammals these messengers act directly on TTFLs via the calcium/cAMP-dependent transcription factor, CREB. In the fruit fly, Drosophila melanogaster, calcium and cAMP also regulate the periodicity of circadian locomotor activity rhythmicity, but whether this is due to direct actions on the TTFLs themselves or are a consequence of changes induced to the complex interrelationship between different classes of central pacemaker neurons is unclear. Here we investigated this question focusing oPLoS geneticsCalcium and cAMP directly modulate the speed of the Drosophila circadian clock.PMC60079363160177114127824110076P09-022-F (CINV)N62909-14-1-N205Ewer JPalacios-Munoz AfalseCalcium and cAMP directly modulate the speed of the Drosophila circadian clock.Circadian clocks impose daily periodicities to animal behavior and physiology. At their core, circadian rhythms are produced by intracellular transcriptional/translational feedback loops (TTFL). TTFLs may be altered by extracellular signals whose actions are mediated intracellularly by calcium and cAMP. In mammals these messengers act directly on TTFLs via the calcium/cAMP-dependent transcription factor, CREB. In the fruit fly, Drosophila melanogaster, calcium and cAMP also regulate the periodicity of circadian locomotor activity rhythmicity, but whether this is due to direct actions on the TTFLs themselves or are a consequence of changes induced to the complex interrelationship between different classes of central pacemaker neurons is unclear. Here we investigated this question focusing o2018-01-01T00:00:00Z2018 Jun2026-04-08T04:32:25.872Z2019-03-26T23:42:33ZS-EPMC60079362987912310.1371/journal.pgen.1007433