biostudies-literatureProspective Studies Collaboration and Asia Pacific Cohort Studies CollaborationKidney Research UKBritish Heart FoundationCancer Research UKNIA NIH HHSMedical Research CouncilWellcome Trust538-546https://www.ebi.ac.uk/biostudies/studies/S-EPMC6008496biostudies-literatureUnknown6(7)<h4>Background</h4>Several studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of other risk factors is uncertain. We aimed to determine whether differences in established risk factors, such as blood pressure, BMI, smoking, and cholesterol, explain the higher relative risks of vascular mortality among women than among men.<h4>Methods</h4>In our meta-analysis, we obtained individual participant-level data from studies included in the Prospective Studies Collaboration and the Asia Pacific Cohort Studies Collaboration that had obtained baseline information on age, sex, diabetes, total cholesterol, blood pressure, tobacco use, heightThe lancet. Diabetes & endocrinologySex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies.PMC6008496MC_UU_12026/2MC_U137686851MC_UU_12026/3PG/09/024/26857MR/P014550/1JFDKcsf2/2017P01 AG017625MC_U137686857212946/Z/18/ZMR/R007764/1Gnatiuc LCriqui MHBenetos ADuffy SSuh INishimoto YSilbershatz HArima HBachman DLElwood PHart CTunstall-Pedoe HThomsen TEmberson JRImai YHozawa AHughes KKita YKromhout DNeaton JWoo JIida MLam THWillett WImai KHolme IShipley MKeller JLi YHDe Backer GHole DDobson AJHu FBengtsson CBjorkelund CEmpana JLevy DNorton RTornberg SLeren PBroadhurst RSchnohr PMatsutani YNaito YYokoyama TReunanen AWannamethee SGD'Agostino RLee JWhincup PHashimoto TKornitzer MHashimoto SGazes PPan WHBaigent CHalsey JChew SKWelborn TAAssmann GRodgers AAoki NMurayama TLeon DAChambless LHobbs MSaitoh SWoodward MCarstensen JWhitlock GDucimetiere PHjermann ICox CWu ZLBonaa KWald NKnekt PKnuiman MLewington SGoldbourt ULaw MSato SRimm EJousilahti PIso HQizilbash NLuszcz MMeade TKagaya MSorlie PSweetnam PCurb JDClarke RProspective Studies Collaboration and Asia Pacific Cohort Studies CollaborationTamakoshi APeters SHerrington WGChen ZJamrozik KNakachi KVartiainen EBartholomew HOkayama AGillis CNakamura MTanaka HHeng DBoyle ESherliker PKronmal RUeshima HGuize LYarnell JZhang XHMaegawa HLuepker RSritara PDavey Smith GYao SXTominaga STuomilehto JKeil JMacMahon SJacobs DRHo SCSelmer RBlackburn HSharp DArnesen EGu DFTverdal APeto RShimamoto KHuxley RRKim ISJee SHShifu XMorris RDhaliwal SSEliassen HNakayama TPuska PJensen GDe Bacquer DMorris JGiles GGJiang CQOhkubo TNozaki AKitamura ABennett DTomita MCollins RDate CJackson RDuan XFGuasch-Ferre MNietert PJGarcia-Palmieri MHKiyohara YHaheim LHoribe HSutherland SEFang XMarmot MSchulte HJohansen NBKim HCJorgensen TLissner LYoshiike NAromaa ASakata KfalseSex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies.<h4>Background</h4>Several studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of other risk factors is uncertain. We aimed to determine whether differences in established risk factors, such as blood pressure, BMI, smoking, and cholesterol, explain the higher relative risks of vascular mortality among women than among men.<h4>Methods</h4>In our meta-analysis, we obtained individual participant-level data from studies included in the Prospective Studies Collaboration and the Asia Pacific Cohort Studies Collaboration that had obtained baseline information on age, sex, diabetes, total cholesterol, blood pressure, tobacco use, height2018-01-01T00:00:00Z2018 Jul2026-05-05T21:52:36.521Z2025-05-29T20:47:05.646ZS-EPMC60084962975219410.1016/S2213-8587(18)30079-2