{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Furlan A"],"funding":["RFBR","RSF","Swedish Cancer Foundation","NHLBI NIH HHS","Bertil Hållstens Forskningsstiftelse","Knut och Alice Wallenbergs Stiftelse","Swedish Research Council","Söderbergs Foundation","Ragnar Soderbergs stiftelse","Ake Wibergs Stiftelse","European Research Council","NHLBI","Wallenberg Foundation","StratNeuro","Karolinska Institutet","Russian Science Foundation","Stipend for Young Researchers","VR","KI","Swedish Research Council Formas"],"pagination":["eaal3753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6013038"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["357(6346)"],"pubmed_abstract":["Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla."],"pmcid":["PMC6013038"],"funding_grant_id":["award314801","award314806","award314808","PainCells","2015-03387","award314790","CP-2890-2016.4","award314792","award314793","award314794","award314795","award314796","award314797","award314798","award314777","award314799","award314778","award314779","16-04-01243","16-15-10273","R01 HL131768","award314780","17-74-20037","award314783","NIH1R01HL131768","award314784","award314786","award314787","award314800"],"pubmed_authors":["Calvo-Enrique L","Furlan A","Sunadome K","Dyachuk V","Chontorotzea T","Akkuratova N","Petersen J","Kamenev D","Abdo H","Hadjab S","Lallemend F","Topilko P","Usoskin D","Marklund U","Fried K","Kastriti ME","Kharchenko PV","Ernfors P","Memic F","Adameyko I"],"additional_accession":[]},"is_claimable":false,"name":"Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.","description":"Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2026-04-30T09:54:18.987Z","creation":"2019-03-26T23:42:36Z"},"accession":"S-EPMC6013038","cross_references":{"pubmed":["28684471"],"doi":["10.1126/science.aal3753"]}}