{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferrer R"],"funding":["Research grant Instituto de Salud Carlos III (FIS 10/01497)","Research grant Instituto de Salud Carlos III"],"pagination":["167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6013897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention would hasten and improve the appropriateness of empirical antibiotic administration, favor de-escalation, and decrease mortality.<h4>Methods</h4>We prospectively studied all consecutive patients with sepsis/septic shock admitted to 72 intensive care units (ICUs) throughout Spain in two 4-month periods (before and immediately after the 3-month intervention). We compared process-of-care variables (resuscitation bundle and time-to-initiation, appropriateness, and de-escalation of empirical antibiotic treatment) and outcome variables between the two cohorts. The primary"],"journal":["Critical care (London, England)"],"pubmed_title":["Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study."],"pmcid":["PMC6013897"],"funding_grant_id":["CM12/00066"],"pubmed_authors":["Rota JIA","Herrera MJT","Carrillo A","Amador AF","Ocana D","Pozo JC","Valenzuela F","Artigas A","Losada EP","Azcona AL","de la Torre MV","Alvarez HA","Pellejero FN","Gutierrez FD","Ferrer R","Del Mar Cruz M","Feo LF","Rodriguez JP","Perez JC","Martinez ML","Cambra MJL","Gonzalo JA","Ramirez P","de la Cruz PA","Rovira A","Diaz SMC","Violan JS","Yanez H","Gonzalez G","Duran C","Catalan R","Gomez-Casero RB","Parejo JFO","Riera J","Bartolome BJ","Garro P","Alonso JC","Ruiz DP","Acero T","Santos CL","Gonzalez CF","Ordonez JM","Sarrapio J","Prieto F","Aguilar GA","Anton E","Munguira EB","Ramos LL","Valdivia M","Bacelar N","Olaechea P","Gonzalez-Diaz G","Herrejon EP","Barrio MM","Ordonez BM","Diez NB","Cortes PV","Gobernado M","Yebenes JC","Fernandez F","Seijas I","Arenzana A","Antuna JIA","Montero JG","Vera P","Simon A","Gallego JMA","Lomas LT","Monleon MAC","Gandia F","Caballero AC","Suarez D","Ruiz A","Poma EM","Ule DC","Chinesta SS","Rilo MTR","Heredia MS","Martin JC","Vazquez NG","Gomez TR","Azkarate I","Garcia PO","Mota MS","Soto M","Perez MP","Rico N","Bolano SR","Murcia C","Trivez PM","de la Cuesta Martin DR","Abad RD","Castellano M","Allut JLG","Del Mar Martin Velasco M","Mendoza D","Martin MCR","ABISS-Edusepsis Study group","Pinto RV","Alvarez-Rocha L","Torrabadella P","Barbadillo S","Roson JF","Dorado P","Casas JM","Berezo JA","Allue JCT","Alonso AET","Porcar MJB","Loza A","Garcia Delgado F","Sanudo C","Sirvent JM","Goma G","Piacentini E","Galdos P","Garcia A","Rognoni G","Sanpedro F","Valero RR","Delgado JDJ","Moreno AP","Garcia RJ","Zapata L","Garcia PJD","Lerma PA","Gomez FG","Garcia BB","Caballero J","Bonell JM","Berro AMD","Rodriguez JCR","Rubio JMG","Blanco J","Salcedo A","Rocha LA","Pueyo MJL","Dominguez FJD","Sagasti FM","Alvarez M","Lopez RL","Castineiras AP","Zaragoza R","Suberbiola B","Andres FB","de Las Olas Cerezo Arias M","Rencinas AR","Muriel A","Garcia-Montesinos M","Cremades I","Borges M","Ciudad VL","Tuero G"],"additional_accession":[]},"is_claimable":false,"name":"Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study.","description":"<h4>Background</h4>Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention would hasten and improve the appropriateness of empirical antibiotic administration, favor de-escalation, and decrease mortality.<h4>Methods</h4>We prospectively studied all consecutive patients with sepsis/septic shock admitted to 72 intensive care units (ICUs) throughout Spain in two 4-month periods (before and immediately after the 3-month intervention). We compared process-of-care variables (resuscitation bundle and time-to-initiation, appropriateness, and de-escalation of empirical antibiotic treatment) and outcome variables between the two cohorts. The primary","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2026-07-15T16:55:51.801Z","creation":"2026-07-08T03:08:14.898Z"},"accession":"S-EPMC6013897","cross_references":{"pubmed":["29933756"],"doi":["10.1186/s13054-018-2091-0"]}}