{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(10)"],"submitter":["Tang W"],"funding":["National Eye Institute","National Institute of Diabetes and Digestive and Kidney Disease","Clinical Translational Science Center Program","General Clinical Research Centers Program","National Institutes of Health","National Institute of Neurologic Disorders and Stroke"],"pubmed_abstract":["Background
Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and Results
A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase"],"journal":["Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6015340"],"repository":["biostudies-literature"],"pubmed_title":["Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study"],"pmcid":["PMC6015340"],"funding_grant_id":["U01 DK094176","U01 DK094157"],"pubmed_authors":["Hazen S","Li D","McGee P","Lachin J","Tang W","Hoogwerf B"],"additional_accession":[]},"is_claimable":false,"name":"Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study","description":"Background
Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and Results
A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-25T19:52:43.526Z","creation":"2019-03-26T23:44:40Z"},"accession":"S-EPMC6015340","cross_references":{}}