biostudies-literatureUnknown7(10)Tang WNational Eye InstituteNational Institute of Diabetes and Digestive and Kidney DiseaseClinical Translational Science Center ProgramGeneral Clinical Research Centers ProgramNational Institutes of HealthNational Institute of Neurologic Disorders and Stroke<h4>Background</h4> Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. <h4>Methods and Results</h4> A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidaseJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseasehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC6015340biostudies-literatureOxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC StudyPMC6015340U01 DK094176U01 DK094157Hazen SLi DMcGee PLachin JTang WHoogwerf BfalseOxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study<h4>Background</h4> Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. <h4>Methods and Results</h4> A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase2018-01-01T00:00:00Z2018 May2025-04-25T19:52:43.526Z2019-03-26T23:44:40ZS-EPMC6015340