{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(3)"],"submitter":["Velderrain-Rodriguez GR"],"pubmed_abstract":["Mango \"Ataulfo\" peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP's antioxidant activity. The content (HPLC-DAD), antioxidant (DPPH, FRAP, ORAC), and antiproliferative activities (MTT) of free (FP) and chemically-released PP from mango 'Ataulfo' peel after alkaline (AKP) and acid (AP) hydrolysis, were evaluated. AKP fraction was higher (µg/g DW) in gallic acid (GA; 23,816 ± 284) than AP (5610 ± 8) of FR (not detected) fractions. AKP fraction and GA showed the highest antioxidant activity (DPPH/FRAP/ORAC) and GA's antioxidant activity follows a single electron transfer (SET) mechanism. AKP and GA also showed the best antiproliferative activity against human colon adenocarcin"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E695"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6017175"],"repository":["biostudies-literature"],"pubmed_title":["Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of 'Ataulfo' Mango Peel on LS180 Cells."],"pmcid":["PMC6017175"],"pubmed_authors":["Villegas-Ochoa MA","Ayala-Zavala JF","Velderrain-Rodriguez GR","Robles-Zepeda RE","Gonzalez-Aguilar GA","Wall-Medrano A","Torres-Moreno H"],"additional_accession":[]},"is_claimable":false,"name":"Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of 'Ataulfo' Mango Peel on LS180 Cells.","description":"Mango \"Ataulfo\" peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP's antioxidant activity. The content (HPLC-DAD), antioxidant (DPPH, FRAP, ORAC), and antiproliferative activities (MTT) of free (FP) and chemically-released PP from mango 'Ataulfo' peel after alkaline (AKP) and acid (AP) hydrolysis, were evaluated. AKP fraction was higher (µg/g DW) in gallic acid (GA; 23,816 ± 284) than AP (5610 ± 8) of FR (not detected) fractions. AKP fraction and GA showed the highest antioxidant activity (DPPH/FRAP/ORAC) and GA's antioxidant activity follows a single electron transfer (SET) mechanism. AKP and GA also showed the best antiproliferative activity against human colon adenocarcin","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-18T15:23:01.631Z","creation":"2019-03-27T00:06:36Z"},"accession":"S-EPMC6017175","cross_references":{"pubmed":["29562699"],"doi":["10.3390/molecules23030695"]}}