{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sieniawska E"],"funding":["Narodowe Centrum Nauki"],"pagination":["E256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6017462"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["The most commonly used plant source of β-elemene is Curcuma wenyujin Y. H. Chen & C. Ling (syn. of Curcuma aromatic Salisb.) with its content in supercritical CO₂ extract up to 27.83%. However, the other rich source of this compound is Nigella damascena L. essential oil, in which β-elemene accounts for 47%. In this work, the effective protocol for preparative isolation of β-elemene from a new source-N. damascena essential oil-using high performance counter-current chromatography HPCCC was elaborated. Furthermore, since sesquiterpens are known as potent antimicrobials, the need for finding new agents designed to combat multi-drug resistant strains was addressed and the purified target compound and the essential oil were tested for its activity against a panel of Gram-positive and Gram-negat"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Nigella damascena L. Essential Oil-A Valuable Source of β-Elemene for Antimicrobial Testing."],"pmcid":["PMC6017462"],"funding_grant_id":["2013/11/D/NZ7/01613"],"pubmed_authors":["Golus J","Skalicka-Wozniak K","Ginalska G","Sieniawska E","Sawicki R","Swatko-Ossor M"],"additional_accession":[]},"is_claimable":false,"name":"Nigella damascena L. Essential Oil-A Valuable Source of β-Elemene for Antimicrobial Testing.","description":"The most commonly used plant source of β-elemene is Curcuma wenyujin Y. H. Chen & C. Ling (syn. of Curcuma aromatic Salisb.) with its content in supercritical CO₂ extract up to 27.83%. However, the other rich source of this compound is Nigella damascena L. essential oil, in which β-elemene accounts for 47%. In this work, the effective protocol for preparative isolation of β-elemene from a new source-N. damascena essential oil-using high performance counter-current chromatography HPCCC was elaborated. Furthermore, since sesquiterpens are known as potent antimicrobials, the need for finding new agents designed to combat multi-drug resistant strains was addressed and the purified target compound and the essential oil were tested for its activity against a panel of Gram-positive and Gram-negat","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-18T15:22:37.226Z","creation":"2019-03-27T00:06:37Z"},"accession":"S-EPMC6017462","cross_references":{"pubmed":["29382097"],"doi":["10.3390/molecules23020256"]}}