{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang SY"],"funding":["Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education"],"pagination":["E457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6017793"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["Two new lignans, zanthoxyloside C (<b>1</b>) and zanthoxyloside D (<b>2</b>), together with nine known compounds comprising lignans (<b>3</b>-<b>5</b>), flavonoids (<b>6</b>-<b>8</b>), and phenolics (<b>9</b>-<b>11</b>), were isolated from the methanol extract of the stems of <i>Zanthoxylum piperitum.</i> All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds <b>7</b>-<b>10</b> showed peroxyl radical-scavenging capacities and <b>4</b>, <b>6</b>-<b>7</b>, and <b>9</b> showed reducing capacities. Moreover, compounds <b>3</b>, <b>6</b>-<b>9</b>, and <b>11</b> significantly suppressed TRAP activities. These "],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum."],"pmcid":["PMC6017793"],"funding_grant_id":["2009-0093815"],"pubmed_authors":["Tai BH","Kim YH","Lee SH","Yang SY","Jang HD"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum.","description":"Two new lignans, zanthoxyloside C (<b>1</b>) and zanthoxyloside D (<b>2</b>), together with nine known compounds comprising lignans (<b>3</b>-<b>5</b>), flavonoids (<b>6</b>-<b>8</b>), and phenolics (<b>9</b>-<b>11</b>), were isolated from the methanol extract of the stems of <i>Zanthoxylum piperitum.</i> All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds <b>7</b>-<b>10</b> showed peroxyl radical-scavenging capacities and <b>4</b>, <b>6</b>-<b>7</b>, and <b>9</b> showed reducing capacities. Moreover, compounds <b>3</b>, <b>6</b>-<b>9</b>, and <b>11</b> significantly suppressed TRAP activities. These ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-05-05T21:27:08.354Z","creation":"2019-03-27T00:06:37Z"},"accession":"S-EPMC6017793","cross_references":{"pubmed":["29463037"],"doi":["10.3390/molecules23020457"]}}