biostudies-literatureYang SYBasic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of EducationE457https://www.ebi.ac.uk/biostudies/studies/S-EPMC6017793biostudies-literatureUnknown23(2)Two new lignans, zanthoxyloside C (1) and zanthoxyloside D (2), together with nine known compounds comprising lignans (3-5), flavonoids (6-8), and phenolics (9-11), were isolated from the methanol extract of the stems of Zanthoxylum piperitum. All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds 7-10 showed peroxyl radical-scavenging capacities and 4, 6-7, and 9 showed reducing capacities. Moreover, compounds 3, 6-9, and 11 significantly suppressed TRAP activities. These Molecules (Basel, Switzerland)Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum.PMC60177932009-0093815Tai BHKim YHLee SHYang SYJang HDfalseAntioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum.Two new lignans, zanthoxyloside C (1) and zanthoxyloside D (2), together with nine known compounds comprising lignans (3-5), flavonoids (6-8), and phenolics (9-11), were isolated from the methanol extract of the stems of Zanthoxylum piperitum. All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds 7-10 showed peroxyl radical-scavenging capacities and 4, 6-7, and 9 showed reducing capacities. Moreover, compounds 3, 6-9, and 11 significantly suppressed TRAP activities. These 2018-01-01T00:00:00Z2018 Feb2026-05-05T21:27:08.354Z2019-03-27T00:06:37ZS-EPMC60177932946303710.3390/molecules23020457