biostudies-literatureWong KSLNINDS NIH HHS1678-1685https://www.ebi.ac.uk/biostudies/studies/S-EPMC6019568biostudies-literatureUnknown49(7)<h4>Background and purpose</h4>SOCRATES (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), comparing ticagrelor with aspirin in patients with acute cerebral ischemia, found a nonsignificant 11% relative risk reduction for stroke, myocardial infarction, or death (<i>P</i>=0.07). Aspirin intake before randomization could enhance the effect of ticagrelor by conferring dual antiplatelet effect during a high-risk period for subsequent stroke. Therefore, we explored the efficacy and safety of ticagrelor versus aspirin in the patients who received any aspirin the week before randomization.<h4>Methods</h4>A prespecified subgroup analysis in SOCRATES (n=13 199), randomizing patients with acute ischemic stroke (National Institutes of Health Stroke ScStrokeEfficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial.PMC6019568U01 NS062835Knutsson MJohnston SCMolina CALadenvall PEaston JDEvans SRHimmelmann AAmarenco PAlbers GWKasner SEMinematsu KSOCRATES Steering Committee and InvestigatorsDenison HHeld PWang YWong KSLfalseEfficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial.<h4>Background and purpose</h4>SOCRATES (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), comparing ticagrelor with aspirin in patients with acute cerebral ischemia, found a nonsignificant 11% relative risk reduction for stroke, myocardial infarction, or death (<i>P</i>=0.07). Aspirin intake before randomization could enhance the effect of ticagrelor by conferring dual antiplatelet effect during a high-risk period for subsequent stroke. Therefore, we explored the efficacy and safety of ticagrelor versus aspirin in the patients who received any aspirin the week before randomization.<h4>Methods</h4>A prespecified subgroup analysis in SOCRATES (n=13 199), randomizing patients with acute ischemic stroke (National Institutes of Health Stroke Sc2018-01-01T00:00:00Z2018 Jul2026-04-14T13:23:32.257Z2026-04-07T13:42:39.324ZS-EPMC60195682991512310.1161/STROKEAHA.118.02055310.1161/strokeaha.118.020553