{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wolf D"],"funding":["Bundesministerium für Bildung und Forschung"],"pagination":["337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6020358"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Cognitively healthy older people can increase their performance in cognitive tasks through training. However, training effects are mostly limited to the trained task; thus, training effects only poorly transfer to untrained tasks or other contexts, which contributes to reduced adaptation abilities in aging. Stabilizing transfer capabilities in aging would increase the chance of persistent high performance in activities of daily living including longer independency, and prolonged active participation in social life. The trial AgeGain aims at elaborating the physiological brain mechanisms of transfer in aging and supposed major modulators of transfer capability, especially physical activity, cerebral vascular lesions, and amyloid burden.<h4>Methods</h4>This 4-year interven"],"journal":["Trials"],"pubmed_title":["Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study."],"pmcid":["PMC6020358"],"funding_grant_id":["01GQ1425A"],"pubmed_authors":["Kollmann B","Knaepen K","Henf J","Baier B","Struder H","Mierau A","Teipel S","Tuscher O","Drzezga A","German AgeGain study group","Wolf D","Binder H","Bruggen K","Riedel D","Lau E","Fellgiebel A","Sebastian A","Fischer F"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.","description":"<h4>Background</h4>Cognitively healthy older people can increase their performance in cognitive tasks through training. However, training effects are mostly limited to the trained task; thus, training effects only poorly transfer to untrained tasks or other contexts, which contributes to reduced adaptation abilities in aging. Stabilizing transfer capabilities in aging would increase the chance of persistent high performance in activities of daily living including longer independency, and prolonged active participation in social life. The trial AgeGain aims at elaborating the physiological brain mechanisms of transfer in aging and supposed major modulators of transfer capability, especially physical activity, cerebral vascular lesions, and amyloid burden.<h4>Methods</h4>This 4-year interven","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2026-05-01T02:39:16.337Z","creation":"2019-03-26T23:45:09Z"},"accession":"S-EPMC6020358","cross_references":{"pubmed":["29945638"],"doi":["10.1186/s13063-018-2688-2"]}}