{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li G"],"funding":["National Key Program of Clinical Science","Beijing Science &amp; Technology Star Program","Beijing Municipal Science &amp;Technology Commission","Graduate innovation fund of Peking Union Medical College","National Key Research program of China","Union Diabetes Research Talent Fund","Development Program of Beijing Chaoyang Hospital","Beijing Natural Science Foundation"],"pagination":["164-171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6020797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32"],"pubmed_abstract":["Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10<sup>-7</sup>). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10<sup>-4</sup>) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, w"],"journal":["EBioMedicine"],"pubmed_title":["Loss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study."],"pmcid":["PMC6020797"],"funding_grant_id":["(#WBYZ 2011–873","#D111100000611002","JXPY201606","(#2017–1002–1-15","#2004A027"],"pubmed_authors":["Li G","Han L","Fu J","Feng D","Wang Y","Li L","Grant SFA","Li M","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Loss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study.","description":"Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10<sup>-7</sup>). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10<sup>-4</sup>) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, w","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-05T13:14:16.079Z","creation":"2019-03-26T23:44:27Z"},"accession":"S-EPMC6020797","cross_references":{"pubmed":["29903569"],"doi":["10.1016/j.ebiom.2018.05.033"]}}