biostudies-literatureLi GNational Key Program of Clinical ScienceBeijing Science & Technology Star ProgramBeijing Municipal Science &Technology CommissionGraduate innovation fund of Peking Union Medical CollegeNational Key Research program of ChinaUnion Diabetes Research Talent FundDevelopment Program of Beijing Chaoyang HospitalBeijing Natural Science Foundation164-171https://www.ebi.ac.uk/biostudies/studies/S-EPMC6020797biostudies-literatureUnknown32Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10<sup>-7</sup>). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10<sup>-4</sup>) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, wEBioMedicineLoss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study.PMC6020797(#WBYZ 2011–873#D111100000611002JXPY201606(#2017–1002–1-15#2004A027Li GHan LFu JFeng DWang YLi LGrant SFALi MGao SfalseLoss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study.Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10<sup>-7</sup>). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10<sup>-4</sup>) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, w2018-01-01T00:00:00Z2018 Jun2025-04-05T13:14:16.079Z2019-03-26T23:44:27ZS-EPMC60207972990356910.1016/j.ebiom.2018.05.033