{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walker CA"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS","Irma T. Hirschl Trust","NIA NIH HHS","NIMH NIH HHS","Ikerbasque, Basque Foundation for Science","BrightFocus Foundation","National Institute of Mental Health","Ministerio de Economía y Competitividad","National Institute on Aging"],"pagination":["e45435"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6030698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(7)"],"pubmed_abstract":["Neurons frequently encounter neurodegenerative signals first in their periphery. For example, exposure of axons to oligomeric Aβ<sub>1-42</sub> is sufficient to induce changes in the neuronal cell body that ultimately lead to degeneration. Currently, it is unclear how the information about the neurodegenerative insult is transmitted to the soma. Here, we find that the translation of pre-localized but normally silenced sentinel mRNAs in axons is induced within minutes of Aβ<sub>1-42</sub> addition in a Ca<sup>2+</sup>-dependent manner. This immediate protein synthesis following Aβ<sub>1-42</sub> exposure generates a retrograde signaling complex including vimentin. Inhibition of the immediate protein synthesis, knock-down of axonal vimentin synthesis, or inhibition of dynein-dependent transp"],"journal":["EMBO reports"],"pubmed_title":["Aβ<sub>1-42</sub> triggers the generation of a retrograde signaling complex from sentinel mRNAs in axons."],"pmcid":["PMC6030698"],"funding_grant_id":["R36AG050696","T32 HD007430","R01 MH096702","SAF2016‐75292‐R","T32HD007430","R01MH096702","R36 AG050696","SAF2016‐76347‐R"],"pubmed_authors":["Walker CA","Matute C","Hengst U","Randolph LK","Alberdi E","Baleriola J"],"additional_accession":[]},"is_claimable":false,"name":"Aβ<sub>1-42</sub> triggers the generation of a retrograde signaling complex from sentinel mRNAs in axons.","description":"Neurons frequently encounter neurodegenerative signals first in their periphery. For example, exposure of axons to oligomeric Aβ<sub>1-42</sub> is sufficient to induce changes in the neuronal cell body that ultimately lead to degeneration. Currently, it is unclear how the information about the neurodegenerative insult is transmitted to the soma. Here, we find that the translation of pre-localized but normally silenced sentinel mRNAs in axons is induced within minutes of Aβ<sub>1-42</sub> addition in a Ca<sup>2+</sup>-dependent manner. This immediate protein synthesis following Aβ<sub>1-42</sub> exposure generates a retrograde signaling complex including vimentin. Inhibition of the immediate protein synthesis, knock-down of axonal vimentin synthesis, or inhibition of dynein-dependent transp","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2026-05-06T03:53:25.821Z","creation":"2025-05-29T19:21:24.327Z"},"accession":"S-EPMC6030698","cross_references":{"pubmed":["29759981"],"doi":["10.15252/embr.201745435"]}}