biostudies-literatureAndrade-Silva DFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)1261-1284https://www.ebi.ac.uk/biostudies/studies/S-EPMC6030720biostudies-literatureUnknown17(7)The complexity of snake venoms has long been investigated to explore a myriad of biologically active proteins and peptides that are used for immobilizing or killing prey, and are responsible for the pathological effects observed on envenomation. Glycosylation is the main post-translational modification (PTM) of viperid venoms but currently there is little understanding of how protein glycosylation impacts the variation of venom proteomes. We have previously reported that <i>Bothrops</i> venom glycoproteomes contain a core of components that markedly define their composition and parallel their phylogenetic classification. Here we extend those observations to eight <i>Bothrops</i> species evaluating the N-glycomes by LC-MS as assigned cartoon structures and detailing those structures separatMolecular & cellular proteomics : MCPStructures of N-Glycans of <i>Bothrops</i> Venoms Revealed as Molecular Signatures that Contribute to Venom Phenotype in Viperid Snakes.PMC60307202014/12245–02013/13548–42013/07467–1308133/2015–32013/14651–3Travaglia Cardoso SRTran TZelanis ASerrano SMTLopes ASReinhold VAndrade-Silva DAshline DReis MDSfalseStructures of N-Glycans of <i>Bothrops</i> Venoms Revealed as Molecular Signatures that Contribute to Venom Phenotype in Viperid Snakes.The complexity of snake venoms has long been investigated to explore a myriad of biologically active proteins and peptides that are used for immobilizing or killing prey, and are responsible for the pathological effects observed on envenomation. Glycosylation is the main post-translational modification (PTM) of viperid venoms but currently there is little understanding of how protein glycosylation impacts the variation of venom proteomes. We have previously reported that <i>Bothrops</i> venom glycoproteomes contain a core of components that markedly define their composition and parallel their phylogenetic classification. Here we extend those observations to eight <i>Bothrops</i> species evaluating the N-glycomes by LC-MS as assigned cartoon structures and detailing those structures separat2018-01-01T00:00:00Z2018 Jul2025-05-29T19:21:25.225Z2025-05-29T19:21:25.225ZS-EPMC60307202971698810.1074/mcp.RA118.00074810.1074/mcp.ra118.000748