{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(5)"],"submitter":["Liu L"],"pubmed_abstract":["<h4>Background</h4>Musashi1 (MSI1) is a characteristic stem cell marker that regulates the balance between cell self-renewal and differentiation. Evidence has identified MSI1 as a pivotal oncogenic regulator in diverse malignancies. However, little evidence uncovers the role of genetic variations of MSI1 gene in cancer etiology.<h4>Objective</h4>The aim of this study was to investigate the association between genetic variants in the MSI1 gene and lung cancer risk.<h4>Methods</h4>Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.<h4>Results</h4>We "],"journal":["Current genomics"],"pagination":["375-383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6030856"],"repository":["biostudies-literature"],"pubmed_title":["Functional Polymorphism in the <i>MSI1</i> Gene Promoter Confers a Decreased Risk of Lung Cancer in Chinese by Reducing <i>MSI1</i> Expression."],"pmcid":["PMC6030856"],"pubmed_authors":["Nong Q","Liu L","Qiu F","Chen J","Lu J","Wu D","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Functional Polymorphism in the <i>MSI1</i> Gene Promoter Confers a Decreased Risk of Lung Cancer in Chinese by Reducing <i>MSI1</i> Expression.","description":"<h4>Background</h4>Musashi1 (MSI1) is a characteristic stem cell marker that regulates the balance between cell self-renewal and differentiation. Evidence has identified MSI1 as a pivotal oncogenic regulator in diverse malignancies. However, little evidence uncovers the role of genetic variations of MSI1 gene in cancer etiology.<h4>Objective</h4>The aim of this study was to investigate the association between genetic variants in the MSI1 gene and lung cancer risk.<h4>Methods</h4>Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.<h4>Results</h4>We ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2026-05-02T19:49:16.904Z","creation":"2019-03-26T22:50:14Z"},"accession":"S-EPMC6030856","cross_references":{"pubmed":["30065613"],"doi":["10.2174/1389202919666171128151544"]}}