biostudies-literatureUnknown19(5)Liu L<h4>Background</h4>Musashi1 (MSI1) is a characteristic stem cell marker that regulates the balance between cell self-renewal and differentiation. Evidence has identified MSI1 as a pivotal oncogenic regulator in diverse malignancies. However, little evidence uncovers the role of genetic variations of MSI1 gene in cancer etiology.<h4>Objective</h4>The aim of this study was to investigate the association between genetic variants in the MSI1 gene and lung cancer risk.<h4>Methods</h4>Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.<h4>Results</h4>We Current genomics375-383https://www.ebi.ac.uk/biostudies/studies/S-EPMC6030856biostudies-literatureFunctional Polymorphism in the <i>MSI1</i> Gene Promoter Confers a Decreased Risk of Lung Cancer in Chinese by Reducing <i>MSI1</i> Expression.PMC6030856Nong QLiu LQiu FChen JLu JWu DZhou YfalseFunctional Polymorphism in the <i>MSI1</i> Gene Promoter Confers a Decreased Risk of Lung Cancer in Chinese by Reducing <i>MSI1</i> Expression.<h4>Background</h4>Musashi1 (MSI1) is a characteristic stem cell marker that regulates the balance between cell self-renewal and differentiation. Evidence has identified MSI1 as a pivotal oncogenic regulator in diverse malignancies. However, little evidence uncovers the role of genetic variations of MSI1 gene in cancer etiology.<h4>Objective</h4>The aim of this study was to investigate the association between genetic variants in the MSI1 gene and lung cancer risk.<h4>Methods</h4>Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.<h4>Results</h4>We 2018-01-01T00:00:00Z2018 Aug2026-05-02T19:49:16.904Z2019-03-26T22:50:14ZS-EPMC60308563006561310.2174/1389202919666171128151544