biostudies-literatureVersteegden LRMDutch Ministry of Economic Affairs and the states of Gelderland and Overijssel1494-1498https://www.ebi.ac.uk/biostudies/studies/S-EPMC6032829biostudies-literatureUnknown12(6)Collagen has been extensively used as a biomaterial, yet for tubular organ repair, synthetic polymers or metals (e.g., stents) are typically used. In this study, we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time, and possibilities to add bioactive components to the scaffold, such as anticoagulants. Implants were prepared by compression of porous scaffolds consisting of fibrillar type I collagen (1.0-2.0% (w/v)). By applying carbodiimide cross-linking to the compressed scaffolds in their opened position, entropy-driven shape memory was induced. The scaffolds were Journal of tissue engineering and regenerative medicineSelf-expandable tubular collagen implants.PMC6032829PID092042PID101020Daamen WFvan der Vliet JAVersteegden LRMLomme RMLMSchultze Kool LJvan Kuppevelt THTer Meer MfalseSelf-expandable tubular collagen implants.Collagen has been extensively used as a biomaterial, yet for tubular organ repair, synthetic polymers or metals (e.g., stents) are typically used. In this study, we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time, and possibilities to add bioactive components to the scaffold, such as anticoagulants. Implants were prepared by compression of porous scaffolds consisting of fibrillar type I collagen (1.0-2.0% (w/v)). By applying carbodiimide cross-linking to the compressed scaffolds in their opened position, entropy-driven shape memory was induced. The scaffolds were 2018-01-01T00:00:00Z2018 Jun2025-04-25T21:16:46.336Z2019-03-26T23:45:56ZS-EPMC60328292970431210.1002/term.2685