{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":103,"searchCount":0},"additional":{"submitter":["Hethcox JC"],"funding":["NIGMS NIH HHS"],"pagination":["8664-8667"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6033654"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(28)"],"pubmed_abstract":["The development of the first enantioselective transition-metal-catalyzed allylic alkylation providing access to acyclic products bearing vicinal all-carbon quaternary centers is disclosed. The iridium-catalyzed allylic alkylation reaction proceeds with excellent yields and selectivities for a range of malononitrile-derived nucleophiles and trisubstituted allylic electrophiles. The utility of these sterically congested products is explored through a series of diverse chemo- and diastereoselective product transformations to afford a number of highly valuable, densely functionalized building blocks, including those containing vicinal all-carbon quaternary stereocenters."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Enantioselective Synthesis of Vicinal All-Carbon Quaternary Centers via Iridium-Catalyzed Allylic Alkylation."],"pmcid":["PMC6033654"],"funding_grant_id":["F31 GM120804","R01 GM080269"],"pubmed_authors":["Hethcox JC","Stoltz BM","Shockley SE"],"view_count":["103"],"additional_accession":[]},"is_claimable":false,"name":"Enantioselective Synthesis of Vicinal All-Carbon Quaternary Centers via Iridium-Catalyzed Allylic Alkylation.","description":"The development of the first enantioselective transition-metal-catalyzed allylic alkylation providing access to acyclic products bearing vicinal all-carbon quaternary centers is disclosed. The iridium-catalyzed allylic alkylation reaction proceeds with excellent yields and selectivities for a range of malononitrile-derived nucleophiles and trisubstituted allylic electrophiles. The utility of these sterically congested products is explored through a series of diverse chemo- and diastereoselective product transformations to afford a number of highly valuable, densely functionalized building blocks, including those containing vicinal all-carbon quaternary stereocenters.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2020-10-29T14:09:22Z","creation":"2019-07-24T07:31:18Z"},"accession":"S-EPMC6033654","cross_references":{"pubmed":["29750856"],"doi":["10.1002/anie.201804820"]}}