biostudies-literatureUnknown19Pisanu SWe present a proteomic dataset generated from a human serum sample and the enriched/depleted fractions obtained by seven commercial products. This report is related to the research article entitled "Comparative evaluation of seven commercial products for human serum enrichment/depletion by shotgun proteomics" [1]. All samples were analyzed by LC-MS/MS, label free quantitation using the spectral counting approach, and Gene Ontology (GO) annotation. Protein relative abundances and functions were reported.Data in brief1765-1767https://www.ebi.ac.uk/biostudies/studies/S-EPMC6034580biostudies-literatureA human proteomic dataset from untreated and depleted/enriched serum samples.PMC6034580Pagnozzi DPisanu SBiosa GCarcangiu LUzzau SfalseA human proteomic dataset from untreated and depleted/enriched serum samples.We present a proteomic dataset generated from a human serum sample and the enriched/depleted fractions obtained by seven commercial products. This report is related to the research article entitled "Comparative evaluation of seven commercial products for human serum enrichment/depletion by shotgun proteomics" [1]. All samples were analyzed by LC-MS/MS, label free quantitation using the spectral counting approach, and Gene Ontology (GO) annotation. Protein relative abundances and functions were reported.2018-01-01T00:00:00Z2018 Aug2021-02-25T08:29:30Z2019-03-26T23:56:02ZS-EPMC60345802998899610.1016/j.dib.2018.06.042