{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Palmsten K"],"funding":["NICHD NIH HHS"],"pagination":["840-848.e1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6038145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(5)"],"pubmed_abstract":["<h4>Objective</h4>To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments.<h4>Design</h4>Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>1,225,718 deliveries.<h4>Intervention(s)</h4>None.<h4>Main outcomes measure(s)</h4>We assessed associations between IPI and preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) according to live birth or nonlive pregnancy outcome in the previous pregnancy.<h4>Result(s)</h4>In IVF deliveries following previous live birth, risk of PTB was 22.2% for IPI 12 to <24 months (reference); risk of PTB was higher for IPI <12 months (adjusted relative risk [aRR] 1.24, 95% confidence interval [CI] 1.09-1.41) and IPI ≥60 months (aRR 1.12, 95% CI 1.00-1.26). In non-IVF deliveries following live birth, risk of PTB was 6.4% for IPI 12 to <24 months (reference); risk of PTB was higher for IPI <12 and ≥60 months (aRR 1.19, 95% CI 1.16-1.21, for both). In both populations, U-shaped or approximately U-shaped associations were observed for SGA and LBW, although the association of IPI <12 months and SGA was not significant in IVF deliveries. In IVF and non-IVF deliveries following nonlive pregnancy outcome, IPI <12 months was not associated with increased risk of PTB, LBW, or SGA, but IPI ≥60 months was associated with significant increased risk of those outcomes in non-IVF deliveries.<h4>Conclusion(s)</h4>Following live births, IPIs <12 or ≥60 months were associated with higher risks of most adverse perinatal outcomes in both IVF and non-IVF deliveries."],"journal":["Fertility and sterility"],"pubmed_title":["In vitro fertilization, interpregnancy interval, and risk of adverse perinatal outcomes."],"pmcid":["PMC6038145"],"funding_grant_id":["R01 HD080952","R01 HD100579","R00 HD082412"],"pubmed_authors":["Palmsten K","Copeland G","States Monitoring Assisted Reproductive Technology (SMART) Collaborative","Zhang Y","Su HI","Homer MV","Crawford S","Chambers CD","Kirby RS","Kissin DM"],"additional_accession":[]},"is_claimable":false,"name":"In vitro fertilization, interpregnancy interval, and risk of adverse perinatal outcomes.","description":"<h4>Objective</h4>To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments.<h4>Design</h4>Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>1,225,718 deliveries.<h4>Intervention(s)</h4>None.<h4>Main outcomes measure(s)</h4>We assessed associations between IPI and preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) according to live birth or nonlive pregnancy outcome in the previous pregnancy.<h4>Result(s)</h4>In IVF deliveries following previous live birth, risk of PTB was 22.2% for IPI 12 to <24 months (reference); risk of PTB was higher for IPI <12 months (adjusted relative risk [aRR] 1.24, 95% confidence interval [CI] 1.09-1.41) and IPI ≥60 months (aRR 1.12, 95% CI 1.00-1.26). In non-IVF deliveries following live birth, risk of PTB was 6.4% for IPI 12 to <24 months (reference); risk of PTB was higher for IPI <12 and ≥60 months (aRR 1.19, 95% CI 1.16-1.21, for both). In both populations, U-shaped or approximately U-shaped associations were observed for SGA and LBW, although the association of IPI <12 months and SGA was not significant in IVF deliveries. In IVF and non-IVF deliveries following nonlive pregnancy outcome, IPI <12 months was not associated with increased risk of PTB, LBW, or SGA, but IPI ≥60 months was associated with significant increased risk of those outcomes in non-IVF deliveries.<h4>Conclusion(s)</h4>Following live births, IPIs <12 or ≥60 months were associated with higher risks of most adverse perinatal outcomes in both IVF and non-IVF deliveries.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-26T08:21:04.661Z","creation":"2019-06-06T22:52:43Z"},"accession":"S-EPMC6038145","cross_references":{"pubmed":["29778383"],"doi":["10.1016/j.fertnstert.2018.01.019"]}}