{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dos Santos IB"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["1427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6038773"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["The present study focused on the activity of the palladacycle complex DPPE 1.1 on <i>Leishmania (Leishmania) amazonensis</i>. Promastigotes of <i>L. (L.) amazonensis</i> were destroyed <i>in vitro</i> by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold less toxic than those harmful to macrophages. <i>L. (L.) amazonensis</i>-infected BALB/c mice were treated by intralesional injection of DPPE 1.1. Animals treated with 3.5 and 7.0 mg/kg of DPPE 1.1 showed a significant decrease of foot lesion sizes and a parasite load reduction of 93 and 99%, respectively, when compared to untreated controls. Furthermore, DPPE 1.1 was non-toxic to treated animals. The cathepsin B activity of <i>L. (L.) amazonensis</i> amastigotes was inhibite"],"journal":["Frontiers in microbiology"],"pubmed_title":["Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis."],"pmcid":["PMC6038773"],"funding_grant_id":["(2014/06935-4)","#2013/02133-8"],"pubmed_authors":["Garcia DM","Teixeira D","Barbieri CL","da Silva DAM","Longo-Maugeri IM","Katz S","Dos Santos IB","Carmona AK","Paz FACR"],"additional_accession":[]},"is_claimable":false,"name":"Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis.","description":"The present study focused on the activity of the palladacycle complex DPPE 1.1 on <i>Leishmania (Leishmania) amazonensis</i>. Promastigotes of <i>L. (L.) amazonensis</i> were destroyed <i>in vitro</i> by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold less toxic than those harmful to macrophages. <i>L. (L.) amazonensis</i>-infected BALB/c mice were treated by intralesional injection of DPPE 1.1. Animals treated with 3.5 and 7.0 mg/kg of DPPE 1.1 showed a significant decrease of foot lesion sizes and a parasite load reduction of 93 and 99%, respectively, when compared to untreated controls. Furthermore, DPPE 1.1 was non-toxic to treated animals. The cathepsin B activity of <i>L. (L.) amazonensis</i> amastigotes was inhibite","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-26T08:19:46.125Z","creation":"2019-03-26T23:46:55Z"},"accession":"S-EPMC6038773","cross_references":{"pubmed":["30018604"],"doi":["10.3389/fmicb.2018.01427"]}}