biostudies-literatureDos Santos IBFundação de Amparo à Pesquisa do Estado de São Paulo1427https://www.ebi.ac.uk/biostudies/studies/S-EPMC6038773biostudies-literatureUnknown9The present study focused on the activity of the palladacycle complex DPPE 1.1 on <i>Leishmania (Leishmania) amazonensis</i>. Promastigotes of <i>L. (L.) amazonensis</i> were destroyed <i>in vitro</i> by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold less toxic than those harmful to macrophages. <i>L. (L.) amazonensis</i>-infected BALB/c mice were treated by intralesional injection of DPPE 1.1. Animals treated with 3.5 and 7.0 mg/kg of DPPE 1.1 showed a significant decrease of foot lesion sizes and a parasite load reduction of 93 and 99%, respectively, when compared to untreated controls. Furthermore, DPPE 1.1 was non-toxic to treated animals. The cathepsin B activity of <i>L. (L.) amazonensis</i> amastigotes was inhibiteFrontiers in microbiologyLeishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis.PMC6038773(2014/06935-4)#2013/02133-8Garcia DMTeixeira DBarbieri CLda Silva DAMLongo-Maugeri IMKatz SDos Santos IBCarmona AKPaz FACRfalseLeishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis.The present study focused on the activity of the palladacycle complex DPPE 1.1 on <i>Leishmania (Leishmania) amazonensis</i>. Promastigotes of <i>L. (L.) amazonensis</i> were destroyed <i>in vitro</i> by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold less toxic than those harmful to macrophages. <i>L. (L.) amazonensis</i>-infected BALB/c mice were treated by intralesional injection of DPPE 1.1. Animals treated with 3.5 and 7.0 mg/kg of DPPE 1.1 showed a significant decrease of foot lesion sizes and a parasite load reduction of 93 and 99%, respectively, when compared to untreated controls. Furthermore, DPPE 1.1 was non-toxic to treated animals. The cathepsin B activity of <i>L. (L.) amazonensis</i> amastigotes was inhibite2018-01-01T00:00:00Z20182025-04-26T08:19:46.125Z2019-03-26T23:46:55ZS-EPMC60387733001860410.3389/fmicb.2018.01427