{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kelechi TJ"],"funding":["NCATS NIH HHS","NINR NIH HHS"],"pagination":["301-309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6041185"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(4)"],"pubmed_abstract":["<h4>Purpose</h4>The purpose of this study was to examine the efficacy of a self-administered cooling treatment on clinically meaningful differences (CMDs) in symptom changes in patients with chronic venous disease.<h4>Design</h4>Blinded, prospective, randomized controlled trial.<h4>Subjects and setting</h4>Two hundred seventy-six community-dwelling adults 21 years and older with skin changes and/or a healed venous leg ulcer (Clinical-Etiologic-Anatomic-Pathologic [CEAP] 4 and 5 classification) completed the 6-month active treatment period.<h4>Methods</h4>Participants were recruited from wound and medicine clinics and from the general population through referrals or advertisements. Participants were randomly allocated to a sham control cuff or interventional cooling cuff group. Demographic "],"journal":["Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society"],"pubmed_title":["Symptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo: A Randomized Clinical Trial."],"pmcid":["PMC6041185"],"funding_grant_id":["UL1 TR001450","R01 NR012237"],"pubmed_authors":["Kelechi TJ","Dooley MJ","Mueller M","Madisetti M","Prentice MA"],"additional_accession":[]},"is_claimable":false,"name":"Symptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo: A Randomized Clinical Trial.","description":"<h4>Purpose</h4>The purpose of this study was to examine the efficacy of a self-administered cooling treatment on clinically meaningful differences (CMDs) in symptom changes in patients with chronic venous disease.<h4>Design</h4>Blinded, prospective, randomized controlled trial.<h4>Subjects and setting</h4>Two hundred seventy-six community-dwelling adults 21 years and older with skin changes and/or a healed venous leg ulcer (Clinical-Etiologic-Anatomic-Pathologic [CEAP] 4 and 5 classification) completed the 6-month active treatment period.<h4>Methods</h4>Participants were recruited from wound and medicine clinics and from the general population through referrals or advertisements. Participants were randomly allocated to a sham control cuff or interventional cooling cuff group. Demographic ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul/Aug","modification":"2026-04-28T22:57:18.519Z","creation":"2019-07-24T07:31:37Z"},"accession":"S-EPMC6041185","cross_references":{"pubmed":["29846278"],"doi":["10.1097/won.0000000000000441","10.1097/WON.0000000000000441"]}}