biostudies-literatureKelechi TJNCATS NIH HHSNINR NIH HHS301-309https://www.ebi.ac.uk/biostudies/studies/S-EPMC6041185biostudies-literatureUnknown45(4)<h4>Purpose</h4>The purpose of this study was to examine the efficacy of a self-administered cooling treatment on clinically meaningful differences (CMDs) in symptom changes in patients with chronic venous disease.<h4>Design</h4>Blinded, prospective, randomized controlled trial.<h4>Subjects and setting</h4>Two hundred seventy-six community-dwelling adults 21 years and older with skin changes and/or a healed venous leg ulcer (Clinical-Etiologic-Anatomic-Pathologic [CEAP] 4 and 5 classification) completed the 6-month active treatment period.<h4>Methods</h4>Participants were recruited from wound and medicine clinics and from the general population through referrals or advertisements. Participants were randomly allocated to a sham control cuff or interventional cooling cuff group. Demographic Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses SocietySymptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo: A Randomized Clinical Trial.PMC6041185UL1 TR001450R01 NR012237Kelechi TJDooley MJMueller MMadisetti MPrentice MAfalseSymptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo: A Randomized Clinical Trial.<h4>Purpose</h4>The purpose of this study was to examine the efficacy of a self-administered cooling treatment on clinically meaningful differences (CMDs) in symptom changes in patients with chronic venous disease.<h4>Design</h4>Blinded, prospective, randomized controlled trial.<h4>Subjects and setting</h4>Two hundred seventy-six community-dwelling adults 21 years and older with skin changes and/or a healed venous leg ulcer (Clinical-Etiologic-Anatomic-Pathologic [CEAP] 4 and 5 classification) completed the 6-month active treatment period.<h4>Methods</h4>Participants were recruited from wound and medicine clinics and from the general population through referrals or advertisements. Participants were randomly allocated to a sham control cuff or interventional cooling cuff group. Demographic 2018-01-01T00:00:00Z2018 Jul/Aug2026-04-28T22:57:18.519Z2019-07-24T07:31:37ZS-EPMC60411852984627810.1097/won.000000000000044110.1097/WON.0000000000000441