biostudies-literatureYao WNMinistry of Education of the People&apos;s Republic of ChinaNational Natural Science Foundation of ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University2178-2183https://www.ebi.ac.uk/biostudies/studies/S-EPMC6044830biostudies-literatureUnknown2(5)Selagintamarlin A (<b>1</b>), a novel selaginellin analogue featuring the unique motif of 1<i>H</i>-2-benzopyran, a new selaginpulvilin E (<b>2</b>), together with eight known analogues were isolated from <i>Selaginella tamariscina</i>. Their structures were elucidated by extensive spectroscopic analyses. A plausible biosynthetic pathway of <b>1</b> was also postulated. Compound <b>1</b> showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC₅₀ value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). Furthermore, compound <b>1</b> significantly inhibited tubulin polymerization.ACS omegaSelagintamarlin A: A Selaginellin Analogue Possessing a 1<i>H</i>-2-Benzopyran Core from <i>Selaginella tamariscina</i>.PMC604483021431001IRT_16R15CMEMR2016-A028140281720134504110002Wang CGLiang DHua JYao WNWang HSHuang RZZhang BfalseSelagintamarlin A: A Selaginellin Analogue Possessing a 1<i>H</i>-2-Benzopyran Core from <i>Selaginella tamariscina</i>.Selagintamarlin A (<b>1</b>), a novel selaginellin analogue featuring the unique motif of 1<i>H</i>-2-benzopyran, a new selaginpulvilin E (<b>2</b>), together with eight known analogues were isolated from <i>Selaginella tamariscina</i>. Their structures were elucidated by extensive spectroscopic analyses. A plausible biosynthetic pathway of <b>1</b> was also postulated. Compound <b>1</b> showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC₅₀ value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). Furthermore, compound <b>1</b> significantly inhibited tubulin polymerization.2017-01-01T00:00:00Z2017 May2024-12-03T23:12:52.165Z2019-03-26T23:47:33ZS-EPMC60448303002365710.1021/acsomega.7b00209