biostudies-literatureUnknown3(1)Mallick TThe visible fluorescent chromophoric moiety present in the water-soluble photoactive yellow protein (PYP) of <i>Ectothiorhodospira halophila</i> is <i>p</i>-hydroxycinnamic acid linked to the cysteine residue (Cys-69) by a thioester bond and it controls the key photoinduced biological processes of the host organism. In the present work, we have synthesized and characterized three structurally different thiophenyl esters [viz., <i>p-</i>hydroxycinnamic-thiophenyl ester (<b>1</b>), <i>p</i>-<i>N</i>,<i>N</i>-dimethylaminocinnamic-thiophenyl ester (<b>2</b>), and <i>S</i>-phenyl-3-(4-chlorophenyl)-3-(phenylthio)propanethioate (<b>3</b>)] in addition to a novel (to the best of our knowledge) stilbene-type olefinic compound, <i>N</i>¹,<i>N</i>¹,<i>N</i>²,<i>N</iACS omega334-348https://www.ebi.ac.uk/biostudies/studies/S-EPMC6044905biostudies-literatureFluorescent Small Molecules Are BIG Enough To Sense Biomacromolecule: Synthesis of Aromatic Thioesters and Understanding Their Interactions with ctDNA.PMC6044905Ahamed GBatuta SAlam MNMandal DDas SMukherjee MDas NKarmakar AMallick TBegum NAfalseFluorescent Small Molecules Are BIG Enough To Sense Biomacromolecule: Synthesis of Aromatic Thioesters and Understanding Their Interactions with ctDNA.The visible fluorescent chromophoric moiety present in the water-soluble photoactive yellow protein (PYP) of <i>Ectothiorhodospira halophila</i> is <i>p</i>-hydroxycinnamic acid linked to the cysteine residue (Cys-69) by a thioester bond and it controls the key photoinduced biological processes of the host organism. In the present work, we have synthesized and characterized three structurally different thiophenyl esters [viz., <i>p-</i>hydroxycinnamic-thiophenyl ester (<b>1</b>), <i>p</i>-<i>N</i>,<i>N</i>-dimethylaminocinnamic-thiophenyl ester (<b>2</b>), and <i>S</i>-phenyl-3-(4-chlorophenyl)-3-(phenylthio)propanethioate (<b>3</b>)] in addition to a novel (to the best of our knowledge) stilbene-type olefinic compound, <i>N</i>¹,<i>N</i>¹,<i>N</i>²,<i>N</i2018-01-01T00:00:00Z2018 Jan2026-04-29T22:59:58.467Z2019-03-26T23:47:15ZS-EPMC60449053002377810.1021/acsomega.7b01933