biostudies-literature00640Lane-Cordova ADNIDDK NIH HHSNHLBI NIH HHS1127-1134https://www.ebi.ac.uk/biostudies/studies/S-EPMC6045450biostudies-literatureUnknown125(9)<h4>Objective</h4>Determine associations of cardiorespiratory fitness, exercise systolic blood pressure (SBP) and heart rate recovery (HRR) following a maximal exercise test performed years preceding pregnancy with odds of preterm birth (PTB; <37 weeks' gestation) and small for gestational age (SGA; birthweight <10^th percentile) delivery.<h4>Design</h4>Prospective, longitudinal.<h4>Setting</h4>Multi-site, observational cohort study initially consisting of 2787 black and white women aged 18-30 at baseline (1985-86) and followed for 25 years (Y25; 2010-2011).<h4>Population</h4>768 nulliparous women at baseline who reported ?1 live birth by the Y25 exam.<h4>Methods</h4>We used Poisson regression to determine associations of exposures with PTB/SGA.<h4>Main outcome measures</h4>PTB and/or SGA births.<h4>Results</h4>Women with PTB (n = 143) and/or SGA (n = 88) were younger, had completed fewer years of education and were more likely to be black versus women without PTB/SGA (n = 546). Women with PTB/SGA had lower fitness (501 ± 9 versus 535 ± 6 seconds, P < 0.002) and higher submaximal SBP than women without PTB/SGA (144 ± 1 versus 142 ± 1 mmHg, P < 0.04). After adjustment, no exercise test variables were associated with PTB/SGA, though the association with HRR and submaximal SBP approached significance in the subset of women who completed the exercise test <5 years before the index birth.<h4>Conclusions</h4>Neither fitness nor haemodynamic responses to exercise a median of 5 years preceding pregnancy, were associated with PTB/SGA. These findings indicate excess likelihood of PTB/SGA is not detectable by low fitness or exercise haemodynamic responses 5 years preceding pregnancy, but exercise testing, especially HRR and submaximal SBP, may be more useful when conducted closer to the onset of pregnancy.<h4>Tweetable abstract</h4>Exercise testing conducted >5 years before pregnancy may not detect women likely to have PTB/SGA.BJOG : an international journal of obstetrics and gynaecologyCardiorespiratory fitness, exercise haemodynamics and birth outcomes: the Coronary Artery Risk Development in Young Adults Study.PMC6045450HHSN268200900041CR01 DK106201HHSN268201300028CHHSN268201300027CHHSN268201300029CR01 DK090047HHSN268201300026CK01 DK059944HHSN268201300025CLewis CEMontag SBadon SECarnethon MRGreenland PGunderson EPCatov JMSternfeld BLane-Cordova ADDude ASchreiner PJ64falseCardiorespiratory fitness, exercise haemodynamics and birth outcomes: the Coronary Artery Risk Development in Young Adults Study.<h4>Objective</h4>Determine associations of cardiorespiratory fitness, exercise systolic blood pressure (SBP) and heart rate recovery (HRR) following a maximal exercise test performed years preceding pregnancy with odds of preterm birth (PTB; <37 weeks' gestation) and small for gestational age (SGA; birthweight <10^th percentile) delivery.<h4>Design</h4>Prospective, longitudinal.<h4>Setting</h4>Multi-site, observational cohort study initially consisting of 2787 black and white women aged 18-30 at baseline (1985-86) and followed for 25 years (Y25; 2010-2011).<h4>Population</h4>768 nulliparous women at baseline who reported ?1 live birth by the Y25 exam.<h4>Methods</h4>We used Poisson regression to determine associations of exposures with PTB/SGA.<h4>Main outcome measures</h4>PTB and/or SGA births.<h4>Results</h4>Women with PTB (n = 143) and/or SGA (n = 88) were younger, had completed fewer years of education and were more likely to be black versus women without PTB/SGA (n = 546). Women with PTB/SGA had lower fitness (501 ± 9 versus 535 ± 6 seconds, P < 0.002) and higher submaximal SBP than women without PTB/SGA (144 ± 1 versus 142 ± 1 mmHg, P < 0.04). After adjustment, no exercise test variables were associated with PTB/SGA, though the association with HRR and submaximal SBP approached significance in the subset of women who completed the exercise test <5 years before the index birth.<h4>Conclusions</h4>Neither fitness nor haemodynamic responses to exercise a median of 5 years preceding pregnancy, were associated with PTB/SGA. These findings indicate excess likelihood of PTB/SGA is not detectable by low fitness or exercise haemodynamic responses 5 years preceding pregnancy, but exercise testing, especially HRR and submaximal SBP, may be more useful when conducted closer to the onset of pregnancy.<h4>Tweetable abstract</h4>Exercise testing conducted >5 years before pregnancy may not detect women likely to have PTB/SGA.2018-01-01T00:00:00Z2018 Aug2021-02-20T22:35:44Z2019-08-07T07:01:01ZS-EPMC60454502937755210.1111/1471-0528.15146