{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(3)"],"submitter":["Li Q"],"pubmed_abstract":["Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on <i>MALAT1</i> gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP's function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with "],"journal":["Bioscience reports"],"pagination":["BSR20171381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6048208"],"repository":["biostudies-literature"],"pubmed_title":["The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese."],"pmcid":["PMC6048208"],"pubmed_authors":["Li J","Zhang H","Li Q","Yan S","Yu T","Zhu W","Wang H","Zhang B","Wu Y","Yuan Y","Sun K"],"additional_accession":[]},"is_claimable":false,"name":"The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.","description":"Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on <i>MALAT1</i> gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP's function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-06-07T08:51:14.935Z","creation":"2026-06-07T03:12:38.563Z"},"accession":"S-EPMC6048208","cross_references":{"pubmed":["29559566"],"doi":["10.1042/BSR20171381"]}}