biostudies-literatureUnknown38(3)Li QMany long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on <i>MALAT1</i> gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP's function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with Bioscience reportsBSR20171381https://www.ebi.ac.uk/biostudies/studies/S-EPMC6048208biostudies-literatureThe MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.PMC6048208Li JZhang HLi QYan SYu TZhu WWang HZhang BWu YYuan YSun KfalseThe MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on <i>MALAT1</i> gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP's function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with 2018-01-01T00:00:00Z2018 May2026-06-07T08:51:14.935Z2026-06-07T03:12:38.563ZS-EPMC60482082955956610.1042/BSR20171381