biostudies-literatureFenyi AInstitut de FranceEC | Horizon 2020 (European Union Framework Programme for Research and Innovation)Agence Nationale de la Recherche (French National Research Agency)10788https://www.ebi.ac.uk/biostudies/studies/S-EPMC6050226biostudies-literatureUnknown8(1)α-synuclein fibrillar polymorphs, Tau and Aß 1-42 fibrillar assemblies have been shown to propagate, amplify and trigger the formation of protein deposits reminiscent of those present within the central nervous system of patients developing synucleinopathies, tauopathies and amyloid plaques after injection intracerebrally, intramuscularly, intraperitoneally or within the blood stream of model animals. They are thus hazardous and there is need for decontamination and inactivation procedures for laboratory surfaces and non-disposable material. We assessed the effectiveness of different reagents to clean and disassemble potentially pathogenic assemblies adsorbed on non-disposable materials in laboratories. We show that commercial detergents and SDS are way more suited to detach α-synuclein fiScientific reportsAssessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.PMC6050226JPND-NeuTARGETs-ANR-14-JPCD-0002-02grant 116060 - IMPRIND - H2020-JTI-IMI2-2015-07contract DEQ20160334896JPND-SYNACTION-ANR-15-JPWG-0012-03Coens ABousset LFenyi ABellande TMelki RfalseAssessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.α-synuclein fibrillar polymorphs, Tau and Aß 1-42 fibrillar assemblies have been shown to propagate, amplify and trigger the formation of protein deposits reminiscent of those present within the central nervous system of patients developing synucleinopathies, tauopathies and amyloid plaques after injection intracerebrally, intramuscularly, intraperitoneally or within the blood stream of model animals. They are thus hazardous and there is need for decontamination and inactivation procedures for laboratory surfaces and non-disposable material. We assessed the effectiveness of different reagents to clean and disassemble potentially pathogenic assemblies adsorbed on non-disposable materials in laboratories. We show that commercial detergents and SDS are way more suited to detach α-synuclein fi2018-01-01T00:00:00Z2018 Jul2025-04-05T13:14:14.484Z2019-03-26T23:47:07ZS-EPMC60502263001832710.1038/s41598-018-28856-2