{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Lin Y"],"pubmed_abstract":["Damage accumulation is widely accepted as the central dogma of ageing, and it has been a long-standing belief that tobacco smokers must experience a faster rate of ageing than non-smokers. It is therefore puzzling as to why proportional hazard model is a popular choice in longitudinal studies given that its assumption assumes a constant hazard with increasing time. If the rate of ageing is accelerated, the hazard gradient of smokers d(log(μ(x)))/dx obtained from frailty parametric fit has to be steeper than non-smokers. This study examines the relative derivative for mortality d(log(μ(x)))/dx of British doctors born 1900-1909, and obtained estimates indicate that the rate of ageing is similar between smokers and non-smokers. A brief theorem is also elaborated to present the difference in l"],"journal":["Scientific reports"],"pagination":["10782"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6050328"],"repository":["biostudies-literature"],"pubmed_title":["The Oddity of Heterogeneity: A Blessing in Disguise."],"pmcid":["PMC6050328"],"pubmed_authors":["Lin Y"],"additional_accession":[]},"is_claimable":false,"name":"The Oddity of Heterogeneity: A Blessing in Disguise.","description":"Damage accumulation is widely accepted as the central dogma of ageing, and it has been a long-standing belief that tobacco smokers must experience a faster rate of ageing than non-smokers. It is therefore puzzling as to why proportional hazard model is a popular choice in longitudinal studies given that its assumption assumes a constant hazard with increasing time. If the rate of ageing is accelerated, the hazard gradient of smokers d(log(μ(x)))/dx obtained from frailty parametric fit has to be steeper than non-smokers. This study examines the relative derivative for mortality d(log(μ(x)))/dx of British doctors born 1900-1909, and obtained estimates indicate that the rate of ageing is similar between smokers and non-smokers. A brief theorem is also elaborated to present the difference in l","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-05T13:13:57.197Z","creation":"2019-03-26T23:47:07Z"},"accession":"S-EPMC6050328","cross_references":{"pubmed":["30018398"],"doi":["10.1038/s41598-018-29081-7"]}}