biostudies-literaturePernet FAgence Nationale de la Recherche (French National Research Agency)10869https://www.ebi.ac.uk/biostudies/studies/S-EPMC6052024biostudies-literatureUnknown8(1)Marine diseases have major impacts on ecosystems and economic consequences for aquaculture and fisheries. Understanding origin, spread and risk factors of disease is crucial for management, but data in the ocean are limited compared to the terrestrial environment. Here we investigated how the marine environment drives the spread of viral disease outbreak affecting The Pacific oyster worldwide by using a spatial epidemiology framework. We collected environmental and oyster health data at 46 sites spread over an area of 300 km² along an inshore-offshore gradient during an epizootic event and conducted risk analysis. We found that disease broke out in the intertidal farming area and spread seaward. Mortalities and virus detection were observed in oysters placed 2 km from the farminScientific reportsDetermination of risk factors for herpesvirus outbreak in oysters using a broad-scale spatial epidemiology framework.PMC6052024ANR-12-AGRO-0001-01Gernez PFleury EMazurie JBouget JFPetton BDaigle GFuhrmann MPernet FfalseDetermination of risk factors for herpesvirus outbreak in oysters using a broad-scale spatial epidemiology framework.Marine diseases have major impacts on ecosystems and economic consequences for aquaculture and fisheries. Understanding origin, spread and risk factors of disease is crucial for management, but data in the ocean are limited compared to the terrestrial environment. Here we investigated how the marine environment drives the spread of viral disease outbreak affecting The Pacific oyster worldwide by using a spatial epidemiology framework. We collected environmental and oyster health data at 46 sites spread over an area of 300 km² along an inshore-offshore gradient during an epizootic event and conducted risk analysis. We found that disease broke out in the intertidal farming area and spread seaward. Mortalities and virus detection were observed in oysters placed 2 km from the farmin2018-01-01T00:00:00Z2018 Jul2025-04-18T18:13:37.994Z2019-03-26T23:47:37ZS-EPMC60520243002208810.1038/s41598-018-29238-4