{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(8)"],"submitter":["Chang J"],"pubmed_abstract":["Methanotrophs synthesize methanobactin, a secondary metabolite that binds copper with an unprecedentedly high affinity. Such a strategy may provide methanotrophs a \"copper monopoly\" that can inhibit the activity of copper-containing enzymes of other microbes, e.g., copper-dependent N<sub>2</sub>O reductases. Here, we show that methanobactin from Methylosinus trichosporium OB3b inhibited N<sub>2</sub>O reduction in denitrifiers. When Pseudomonas stutzeri DCP-Ps1 was incubated in cocultures with M. trichosporium OB3b or with purified methanobactin from M. trichosporium OB3b, stoichiometric N<sub>2</sub>O production was observed from NO<sub>3</sub><sup>-</sup> reduction, whereas no significant N<sub>2</sub>O accumulation was observed in cocultures with a mutant defective in methanobactin prod"],"journal":["The ISME journal"],"pagination":["2086-2089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6052078"],"repository":["biostudies-literature"],"pubmed_title":["Methanobactin from Methylosinus trichosporium OB3b inhibits N<sub>2</sub>O reduction in denitrifiers."],"pmcid":["PMC6052078"],"pubmed_authors":["DiSpirito AA","Gu W","Yoon S","Chang J","Semrau JD","Park D"],"additional_accession":[]},"is_claimable":false,"name":"Methanobactin from Methylosinus trichosporium OB3b inhibits N<sub>2</sub>O reduction in denitrifiers.","description":"Methanotrophs synthesize methanobactin, a secondary metabolite that binds copper with an unprecedentedly high affinity. Such a strategy may provide methanotrophs a \"copper monopoly\" that can inhibit the activity of copper-containing enzymes of other microbes, e.g., copper-dependent N<sub>2</sub>O reductases. Here, we show that methanobactin from Methylosinus trichosporium OB3b inhibited N<sub>2</sub>O reduction in denitrifiers. When Pseudomonas stutzeri DCP-Ps1 was incubated in cocultures with M. trichosporium OB3b or with purified methanobactin from M. trichosporium OB3b, stoichiometric N<sub>2</sub>O production was observed from NO<sub>3</sub><sup>-</sup> reduction, whereas no significant N<sub>2</sub>O accumulation was observed in cocultures with a mutant defective in methanobactin prod","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2026-05-05T23:12:53.447Z","creation":"2019-08-07T07:01:11Z"},"accession":"S-EPMC6052078","cross_references":{"pubmed":["29330532"],"doi":["10.1038/s41396-017-0022-8"]}}