biostudies-literatureToth RIntramural NIH HHSCancer Research UKNHGRI NIH HHSNational Institute for Health Research (NIHR)NCI NIH HHSWellcome Trust816-825https://www.ebi.ac.uk/biostudies/studies/S-EPMC6054308biostudies-literatureUnknown26(6)<b>Background:</b> Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background.<b>Methods:</b> In a subsets (ASSET) meta-analytic approach, we investigated associations of genetic variants related to epigenetic mechanisms with risks of breast, lung, colorectal, ovarian and prostate carcinomas using 51,724 cases and 52,001 controls. False discovery rate-corrected <i>P</i> values (q values < 0.05) were considered statistically significant.<b>Results:</b> Among 162,887 imputed or genotyped variants in 555 candidate genes, SNPs in eight genes were associated with risk of more than one cancer type. For example, variants in <i>BABAM1</i> were confirmed as a susceptibility locus for squamous cell lung, overall breCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyGenetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.PMC6054308R35 CA197735U01 HG004446U19 CA148537P01 CA087969U01 CA098233U01 CA167551U01 CA098710U01 CA098758Z01 CP010200P30 CA014089UM1 CA167551R01 CA122443U01 CA0982161500717528R01 CA151993U19 CA148065R01 CA076366U19 CA148127U01 HG004438U19 CA148107U01 CA122839C5047/A7357U01 CA181770R01 CA081488R01 CA143237076113NF-SI-0510-10096P50 CA136393P30 CA015083P50 CA127003U19 CA148112R01 CA136726R01 CA144040UM1 CA186107Eeles RAHazra AToth RKelemen LERisch AYe YScherer DIssa JJOgino SOCAC, CORECT, TRICL, ELLIPSE, DRIVE, and GAME-ON consortiaMoreno VHung RJUlrich CMBalavarca YWu XGoode ELfalseGenetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.<b>Background:</b> Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background.<b>Methods:</b> In a subsets (ASSET) meta-analytic approach, we investigated associations of genetic variants related to epigenetic mechanisms with risks of breast, lung, colorectal, ovarian and prostate carcinomas using 51,724 cases and 52,001 controls. False discovery rate-corrected <i>P</i> values (q values < 0.05) were considered statistically significant.<b>Results:</b> Among 162,887 imputed or genotyped variants in 555 candidate genes, SNPs in eight genes were associated with risk of more than one cancer type. For example, variants in <i>BABAM1</i> were confirmed as a susceptibility locus for squamous cell lung, overall bre2017-01-01T00:00:00Z2017 Jun2026-05-02T19:51:44.196Z2019-03-26T23:47:17ZS-EPMC60543082811540610.1158/1055-9965.EPI-16-072810.1158/1055-9965.epi-16-0728