{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yi L"],"funding":["American Cancer Society","NIAID NIH HHS","National Natural Science Foundation of China","NCI NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["1509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6058043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Natural products and their derivatives have long been used as pharmacological agents in the fight against cancer. Human natural killer (NK) cells are critical in our immune system in that they are capable of destroying tumor cells directly. However, there are few reports that elucidate the role of natural products in activating NK cells. In this study, we discovered that a synthetic disaccharide derivative of diphyllin, 4-<i>O</i>-{[2'',3'',4''-tri-<i>O</i>-acetyl-α-D-arabinopyranosyl-(1''→4')]-2',3'-di-<i>O</i>-acetyl-α-L-rhamnopyranosyl}diphyllin (TAARD), can alone stimulate interferon (IFN)-γ secretion in primary human NK cells and the NKL cell line. Additionally, it had an additive effect with IL-12 or IL-15 on IFN-γ production, but little adverse effects on NK cells. Mechanistically, "],"journal":["Frontiers in immunology"],"pubmed_title":["A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma <i>via</i> Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways."],"pmcid":["PMC6058043"],"funding_grant_id":["P30 CA016058","CA185301, AI129582, NS106170","RSG-14-243-01-LIB","R01 NS106170","R01 CA185301","31571991, 21372132, 81673155","2017YFD0200900","R01 AI129582"],"pubmed_authors":["Kinghorn AD","Zhang J","Wang LS","Fan Z","Guo X","Chen L","Ren Y","Wang H","Yu J","Ji X","Yi L","Huang X","Pan P","Lu T","Caligiuri MA"],"additional_accession":[]},"is_claimable":false,"name":"A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma <i>via</i> Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways.","description":"Natural products and their derivatives have long been used as pharmacological agents in the fight against cancer. Human natural killer (NK) cells are critical in our immune system in that they are capable of destroying tumor cells directly. However, there are few reports that elucidate the role of natural products in activating NK cells. In this study, we discovered that a synthetic disaccharide derivative of diphyllin, 4-<i>O</i>-{[2'',3'',4''-tri-<i>O</i>-acetyl-α-D-arabinopyranosyl-(1''→4')]-2',3'-di-<i>O</i>-acetyl-α-L-rhamnopyranosyl}diphyllin (TAARD), can alone stimulate interferon (IFN)-γ secretion in primary human NK cells and the NKL cell line. Additionally, it had an additive effect with IL-12 or IL-15 on IFN-γ production, but little adverse effects on NK cells. Mechanistically, ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-03T22:14:15.494Z","creation":"2019-03-26T23:49:49Z"},"accession":"S-EPMC6058043","cross_references":{"pubmed":["30072983"],"doi":["10.3389/fimmu.2018.01509"]}}