{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nakabayashi M"],"funding":["Japan Society for the Promotion of Science (JSPS)","Japan Society for the Promotion of Science"],"pagination":["11205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6060170"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["The discovery of circulating tumour DNA molecules created a paradigm shift in tumour biomarkers as predictors of recurrence. Non-invasive prenatal testing (NIPT) to detect circulating cell-free foetal DNA in maternal plasma is increasingly recognised as a valuable substitute to perceive foetal copy number variation (CNV). This study aimed to determine whether the copy number detection in plasma samples using NIPT platform could be used as a prognostic biomarker in patients with gynaecological cancer. We conducted a prospective study using samples containing preoperative plasma from 100 women with gynaecological cancers. Samples were randomly rearranged and blindly sequenced using a low-coverage whole-genome sequencing plasma DNA, NIPT platform. The NIPT pipeline identified copy number alte"],"journal":["Scientific reports"],"pubmed_title":["Massively parallel sequencing of cell-free DNA in plasma for detecting gynaecological tumour-associated copy number alteration."],"pmcid":["PMC6060170"],"funding_grant_id":["JP15K15612","JP17K16311","JP16K20211"],"pubmed_authors":["Miyamoto S","Iizuka C","Nakabayashi M","Sekizawa A","Kawashima A","Yasuhara R","Hayakawa Y"],"additional_accession":[]},"is_claimable":false,"name":"Massively parallel sequencing of cell-free DNA in plasma for detecting gynaecological tumour-associated copy number alteration.","description":"The discovery of circulating tumour DNA molecules created a paradigm shift in tumour biomarkers as predictors of recurrence. Non-invasive prenatal testing (NIPT) to detect circulating cell-free foetal DNA in maternal plasma is increasingly recognised as a valuable substitute to perceive foetal copy number variation (CNV). This study aimed to determine whether the copy number detection in plasma samples using NIPT platform could be used as a prognostic biomarker in patients with gynaecological cancer. We conducted a prospective study using samples containing preoperative plasma from 100 women with gynaecological cancers. Samples were randomly rearranged and blindly sequenced using a low-coverage whole-genome sequencing plasma DNA, NIPT platform. The NIPT pipeline identified copy number alte","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-19T17:56:10.61Z","creation":"2019-03-27T00:03:42Z"},"accession":"S-EPMC6060170","cross_references":{"pubmed":["30046040"],"doi":["10.1038/s41598-018-29381-y"]}}