{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["164(2)"],"submitter":["Kamelia L"],"funding":["Concawe"],"pubmed_abstract":["Recent evidence suggests that the interaction of polycyclic aromatic hydrocarbons (PAHs), present in some petroleum substances (PS), with particular nuclear-hormone-receptors and/or the dioxin (aryl hydrocarbon receptor [AhR]) receptor, may play a role in the prenatal developmental toxicity (PDT) induced by these substances. To address this hypothesis, we evaluated the possible endocrine and dioxin-like activity of the dimethylsulfoxide (DMSO)-extracts of 9 PS, varying in PAH content, and 2 gas-to-liquid (GTL) products, containing no PAHs but having similar other properties as PS, using a series of Chemical Activated LUciferase gene eXpression (CALUX) assays. The results show that the extracts of PS tested in this study possess various endocrine and dioxin-like activities and these in vitr"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pagination":["576-591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6061685"],"repository":["biostudies-literature"],"pubmed_title":["The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays."],"pmcid":["PMC6061685"],"pubmed_authors":["Kamelia L","Maslowska-Gornicz A","Ketelslegers HB","Boogaard PJ","de Haan L","Louisse J","Rietjens IMCM","Brouwer A"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays.","description":"Recent evidence suggests that the interaction of polycyclic aromatic hydrocarbons (PAHs), present in some petroleum substances (PS), with particular nuclear-hormone-receptors and/or the dioxin (aryl hydrocarbon receptor [AhR]) receptor, may play a role in the prenatal developmental toxicity (PDT) induced by these substances. To address this hypothesis, we evaluated the possible endocrine and dioxin-like activity of the dimethylsulfoxide (DMSO)-extracts of 9 PS, varying in PAH content, and 2 gas-to-liquid (GTL) products, containing no PAHs but having similar other properties as PS, using a series of Chemical Activated LUciferase gene eXpression (CALUX) assays. The results show that the extracts of PS tested in this study possess various endocrine and dioxin-like activities and these in vitr","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-04T09:45:58.071Z","creation":"2019-03-26T23:49:51Z"},"accession":"S-EPMC6061685","cross_references":{"pubmed":["29726971"],"doi":["10.1093/toxsci/kfy114"]}}