{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(6)"],"submitter":["Ji X"],"pubmed_abstract":["The role of ambient air pollution is considered to be important in the development of chronic obstructive pulmonary disease (COPD), and pulmonary hypertension (PH) is a common clinical manifestation of COPD. However, many studies have mainly focused on the adverse health effects of a single air pollutant, ignoring the combined toxicity of multiple pollutants. In the present study, we co-exposed mice to coal-burning air pollutants (SO<sub>2</sub>, NO<sub>2</sub> and PM<sub>2.5</sub>), and confirmed PH-like injury occurrence by airflow limitation, marked abnormal endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) expression, and histopathological and ultrastructural alteration. Global microRNA (miRNA) arrays identified three significantly changed miRNAs homologous with humans ("],"journal":["Toxicology research"],"pagination":["1548-1560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6062392"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO<sub>2</sub>, NO<sub>2</sub> and PM<sub>2.5</sub> co-exposure through targeting the HIF-1α/Fhl-1 pathway."],"pmcid":["PMC6062392"],"pubmed_authors":["Li G","Ji X","Zhang Y","Yun Y","Sang N","Ku T"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO<sub>2</sub>, NO<sub>2</sub> and PM<sub>2.5</sub> co-exposure through targeting the HIF-1α/Fhl-1 pathway.","description":"The role of ambient air pollution is considered to be important in the development of chronic obstructive pulmonary disease (COPD), and pulmonary hypertension (PH) is a common clinical manifestation of COPD. However, many studies have mainly focused on the adverse health effects of a single air pollutant, ignoring the combined toxicity of multiple pollutants. In the present study, we co-exposed mice to coal-burning air pollutants (SO<sub>2</sub>, NO<sub>2</sub> and PM<sub>2.5</sub>), and confirmed PH-like injury occurrence by airflow limitation, marked abnormal endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) expression, and histopathological and ultrastructural alteration. Global microRNA (miRNA) arrays identified three significantly changed miRNAs homologous with humans (","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-04T09:46:40.244Z","creation":"2019-03-26T23:50:41Z"},"accession":"S-EPMC6062392","cross_references":{"pubmed":["30090456"],"doi":["10.1039/c6tx00257a"]}}