biostudies-literatureGranchelli AMDOD | Army Research OfficeClaudia Ruth Goodrich Stevens Family Endowment FundCystic Fibrosis FoundationHHS | NIH | National Cancer InstituteRCUK | Medical Research CouncilBen B and Iris M Margolis FoundationHHS | NIH | National Heart, Lung, and Blood InstituteNational Science Foundatione00354-18https://www.ebi.ac.uk/biostudies/studies/S-EPMC6062800biostudies-literatureUnknown56(8)Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We used generalized estimating equations to fit logistic regression models to longitudinal 2-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003 to 2011, in order to study associations between the airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient. Adjusted models were tested for sensitivity to cystic fibrosis-specific treatments. The study included 28,042 patients aged 6 years and older from 257 accredited U.S. care centers and affiliates. These patients had pJournal of clinical microbiologyMicrobial Interactions in the Cystic Fibrosis Airway.PMC6062800RTG: NSF-DMS 1148230T32HL105321R01HL125520LIOU14P0ARO W911NF-15-1-0400CC132-16ADU54 CA209978MR/M014827/1Keogh RHCox DRGranchelli AMLiou TGKartsonaki CAdler FRfalseMicrobial Interactions in the Cystic Fibrosis Airway.Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We used generalized estimating equations to fit logistic regression models to longitudinal 2-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003 to 2011, in order to study associations between the airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient. Adjusted models were tested for sensitivity to cystic fibrosis-specific treatments. The study included 28,042 patients aged 6 years and older from 257 accredited U.S. care centers and affiliates. These patients had p2018-01-01T00:00:00Z2018 Aug2025-04-04T08:44:19.61Z2019-03-26T22:39:22ZS-EPMC60628002976927910.1128/JCM.00354-1810.1128/jcm.00354-18