{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Cho S"],"pubmed_abstract":["<sub>L</sub>-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of <sub>L</sub>-ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of <sub>L</sub>-ascorbic acid. In this study, we demonstrate that <sub>L</sub>-ascorbic acid treatment showed efficient anti-cancer activity in cell lines with high expression levels of SVCT-2 for a gradient concentration of <sub>L</sub>-ascorbic acid from 10 μM -2 mM. However, in low SVCT-2 expressing cell lines, high-dose <sub>L</sub>-ascorbic acid (>1 mM) showed anti-cancer effects but low-dose (<10 μM) treatment induced cell proliferation. Such conflicting results"],"journal":["Scientific reports"],"pagination":["11372"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6063950"],"repository":["biostudies-literature"],"pubmed_title":["Hormetic dose response to <sub>L</sub>-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression."],"pmcid":["PMC6063950"],"pubmed_authors":["Roh K","Lee S","Kil EJ","Byun HS","Yoo BC","Yeom CH","Cho SH","Song H","Park S","Shin H","Kim Y","Cho S","Chae JS","Shin Y"],"additional_accession":[]},"is_claimable":false,"name":"Hormetic dose response to <sub>L</sub>-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression.","description":"<sub>L</sub>-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of <sub>L</sub>-ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of <sub>L</sub>-ascorbic acid. In this study, we demonstrate that <sub>L</sub>-ascorbic acid treatment showed efficient anti-cancer activity in cell lines with high expression levels of SVCT-2 for a gradient concentration of <sub>L</sub>-ascorbic acid from 10 μM -2 mM. However, in low SVCT-2 expressing cell lines, high-dose <sub>L</sub>-ascorbic acid (>1 mM) showed anti-cancer effects but low-dose (<10 μM) treatment induced cell proliferation. Such conflicting results","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-05-18T11:29:02.564Z","creation":"2025-05-18T11:29:02.564Z"},"accession":"S-EPMC6063950","cross_references":{"pubmed":["30054560"],"doi":["10.1038/s41598-018-29386-7"]}}