biostudies-literatureLinet MSChinese Center for Disease Control and PreventionCGH CDC HHSIntramural Research Program of the National Institutes of Health, National Cancer Institute, and the U.S. Public Health Service of the Department of Health and Human ServicesCooperative Agreements from the U.S. Centers for Disease Control and Prevneitone022394https://www.ebi.ac.uk/biostudies/studies/S-EPMC6067353biostudies-literatureUnknown8(7)<h4>Objective</h4>To determine the feasibility of long-term prospective follow-up and ascertainment of cancer in offspring and mothers from the 1993-1995 Chinese Community Intervention Program that provided folic acid supplements before and during early pregnancy to reduce neural tube defects.<h4>Design</h4>Feasibility pilot study for a prospective cohort study.<h4>Setting</h4>Families residing during 2012-2013 in one rural and one urban county from 21 counties in 3 provinces in China included in the Community Intervention Program campaign.<h4>Participants</h4>The feasibility study targeted 560 families, including 280 from the rural and 280 from the urban county included in the large original study; about half of mothers in each group had taken and half had not taken folic acid supplementsBMJ openProspective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families.PMC6067353U01 GH000029Liang XLu XWang BHao LBerry RJWang HZhang LWan WWang LMu CWang NFan JCong SWang YTang YPotischman NKitahara CMLinet MSSun XChao AMeng FLi ZLv FYin PYang RSampson JFang LLiu FfalseProspective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families.<h4>Objective</h4>To determine the feasibility of long-term prospective follow-up and ascertainment of cancer in offspring and mothers from the 1993-1995 Chinese Community Intervention Program that provided folic acid supplements before and during early pregnancy to reduce neural tube defects.<h4>Design</h4>Feasibility pilot study for a prospective cohort study.<h4>Setting</h4>Families residing during 2012-2013 in one rural and one urban county from 21 counties in 3 provinces in China included in the Community Intervention Program campaign.<h4>Participants</h4>The feasibility study targeted 560 families, including 280 from the rural and 280 from the urban county included in the large original study; about half of mothers in each group had taken and half had not taken folic acid supplements2018-01-01T00:00:00Z2018 Jul2025-04-18T14:15:40.07Z2019-03-26T23:49:10ZS-EPMC60673533006144610.1136/bmjopen-2018-022394