{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Simon-Martinez C"],"funding":["Onderzoeksraad, KU Leuven","Fonds Wetenschappelijk Onderzoek"],"pagination":["250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6069849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Upper limb (UL) deficits in children with unilateral cerebral palsy (uCP) have traditionally been targeted with motor execution treatment models, such as modified Constraint-Induced Movement Therapy (mCIMT). However, new approaches based on a neurophysiological model such as Action-Observation Training (AOT) may provide new opportunities for enhanced motor learning. The aim of this study is to describe a randomised controlled trial (RCT) protocol investigating the effects of an intensive treatment model, combining mCIMT and AOT compared to mCIMT alone on UL function in children with uCP. Additionally, the role of neurological factors as potential biomarkers of treatment response will be analysed.<h4>Methods</h4>An evaluator-blinded RCT will be conducted in 42 children ag"],"journal":["BMC pediatrics"],"pubmed_title":["Combining constraint-induced movement therapy and action-observation training in children with unilateral cerebral palsy: a randomized controlled trial."],"pmcid":["PMC6069849"],"funding_grant_id":["3M140230","G087213N"],"pubmed_authors":["Sgandurra G","Klingels K","Mailleux L","Molenaers G","Ortibus E","Simon-Martinez C","Demaerel P","Sunaert S","Cioni G","Fehrenbach A","Desloovere K","Feys H","Wenderoth N"],"additional_accession":[]},"is_claimable":false,"name":"Combining constraint-induced movement therapy and action-observation training in children with unilateral cerebral palsy: a randomized controlled trial.","description":"<h4>Background</h4>Upper limb (UL) deficits in children with unilateral cerebral palsy (uCP) have traditionally been targeted with motor execution treatment models, such as modified Constraint-Induced Movement Therapy (mCIMT). However, new approaches based on a neurophysiological model such as Action-Observation Training (AOT) may provide new opportunities for enhanced motor learning. The aim of this study is to describe a randomised controlled trial (RCT) protocol investigating the effects of an intensive treatment model, combining mCIMT and AOT compared to mCIMT alone on UL function in children with uCP. Additionally, the role of neurological factors as potential biomarkers of treatment response will be analysed.<h4>Methods</h4>An evaluator-blinded RCT will be conducted in 42 children ag","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2026-05-05T23:26:18.327Z","creation":"2019-03-26T23:49:58Z"},"accession":"S-EPMC6069849","cross_references":{"pubmed":["30064396"],"doi":["10.1186/s12887-018-1228-2"]}}