biostudies-literatureUnknown187(8)Dhana KNational Heart, Lung, and Blood InstituteWe conducted an epigenome-wide association study on obesity-related traits. We used data from 2 prospective, population-based cohort studies: the Rotterdam Study (RS) (2006-2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990-1992). We used the RS (n = 1,450) as the discovery panel and the ARIC Study (n = 2,097) as the replication panel. Linear mixed-effect models were used to assess the cross-sectional associations between genome-wide DNA methylation in leukocytes and body mass index (BMI) and waist circumference (WC), adjusting for sex, age, smoking, leukocyte proportions, array number, and position on array. The latter 2 variables were modeled as random effects. Fourteen 5'-C-phosphate-G-3' (CpG) sites were associated with BMI and 26 CpG sites with WC in the RS after BonAmerican journal of epidemiology1662-1669https://www.ebi.ac.uk/biostudies/studies/S-EPMC6070087biostudies-literatureAn Epigenome-Wide Association Study of Obesity-Related Traits.PMC6070087Dehghan ADhana KGuan WUitterlinden AGVoortman TDemerath EWFranco OHHofman ANano Jvan Meurs JBJFornage MBraun KVEfalseAn Epigenome-Wide Association Study of Obesity-Related Traits.We conducted an epigenome-wide association study on obesity-related traits. We used data from 2 prospective, population-based cohort studies: the Rotterdam Study (RS) (2006-2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990-1992). We used the RS (n = 1,450) as the discovery panel and the ARIC Study (n = 2,097) as the replication panel. Linear mixed-effect models were used to assess the cross-sectional associations between genome-wide DNA methylation in leukocytes and body mass index (BMI) and waist circumference (WC), adjusting for sex, age, smoking, leukocyte proportions, array number, and position on array. The latter 2 variables were modeled as random effects. Fourteen 5'-C-phosphate-G-3' (CpG) sites were associated with BMI and 26 CpG sites with WC in the RS after Bon2018-01-01T00:00:00Z2018 Aug2025-04-04T20:30:43.867Z2019-08-07T07:01:37ZS-EPMC60700872976263510.1093/aje/kwy025