biostudies-literatureCorlin LNational Institute of Environmental Health SciencesTufts University Department of Civil and Environmental EngineeringTechnology Development and Transfer Division, Department of Science and Technology, Government of IndiaSri Ramachandra University (IN)National Science FoundationTufts Institute of the Environmente0201036https://www.ebi.ac.uk/biostudies/studies/S-EPMC6070252biostudies-literatureUnknown13(8)Urbanization is associated with higher prevalence of cardiovascular disease worldwide. Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wavPloS oneUrbanization as a risk factor for aortic stiffness in a cohort in India.PMC60702520966093ES015462VI-D&P/151/06-07/TDTBrugge DChui KKHThanikachalam MChandrasekaran ACorlin LVijayakumar HKrakoff LSunderarajan JThanikachalam SLane KJfalseUrbanization as a risk factor for aortic stiffness in a cohort in India.Urbanization is associated with higher prevalence of cardiovascular disease worldwide. Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wav2018-01-01T00:00:00Z20182025-04-04T20:30:58.854Z2019-03-26T23:50:24ZS-EPMC60702523006779810.1371/journal.pone.0201036