{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Santi A"],"pubmed_abstract":["Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regu"],"journal":["Translational psychiatry"],"pagination":["142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6070549"],"repository":["biostudies-literature"],"pubmed_title":["Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man."],"pmcid":["PMC6070549"],"pubmed_authors":["Penninx BWJH","Bot M","Aleman A","Aleman IT","Santi A"],"additional_accession":[]},"is_claimable":false,"name":"Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man.","description":"Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regu","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-19T20:57:11.272Z","creation":"2019-03-26T23:49:59Z"},"accession":"S-EPMC6070549","cross_references":{"pubmed":["30068974"],"doi":["10.1038/s41398-018-0196-5"]}}